[2020] On game launch "the handle is invalid" (0x6)

How far do you get when launching the game? Do you see the launcher? Do you get to the main menu?

In that case the best thing is to try the troubleshooting steps in this thread:
https://steamcommunity.com/app/255710/discussions/0/1742265315844206043/

If that doesn't help, I'm afraid you'll have to get in touch with Paradox Support. There are instructions at the end of that thread on how to do that. They can then guide you through the process needed to get you back in the game, and log any bugs that need fixing.