[2022] City Skylines wont open

It sounds like you don't see the Paradox launcher at all. In that case please try the steps in this thread, and if that doesn't work follow the instructions at the end to contact PDX Support.

https://steamcommunity.com/app/255710/discussions/0/1742265315844206043/

Originally posted by NewHack: hello, it still doesn't work sadly, any other suggestions?

Did you contact Paradox support? They can be reached here: https://paradox.zendesk.com/