[2020] Zoning Size Type Difference

For zones everything is calculated per zoning tile, so 2 buildings which are 2x4 will effectively be the same as 1 4x4 building. A benefit to having just 4x4 buildings is you have fewer buildings, which is useful for building very large cities, where you might hit the building limit. On the other hand, you get more variation when you have smaller buildings mixed in, so your zones will look more varied that way.