[2022] Red screen upon entering Sanctum of the Architect

It looks like the log you posted is from a playthrough of the first few chapters, not including Sanctum of the Architect. Do you have a log where you’ve entered that scene? The log from your most recent play session is always named Player.log.

Before reinstalling the game, if you’re playing the game through Steam you can try verifying the files there. In your Steam library, right click Last Epoch → Properties → Local files → Verify integrity of game files.