Keyboard stops working

Hi there, from the way you describe this, the HUD being gone and the fact not even ESC works, I think you may have hit DEL (Delete) which disables the HUD and Main Menu, as well as hiding Loot Labels regardless of your Loot Filter settings.

If this happens again, please try pressing the DEL key to see if that corrects the issue. If it does not, after reloading, please submit an In Game Bug Report with all of this information. The IGBR Tool attached the .log files from the current and previous gameplay sessions so in instances where a reload has been necessary, our team can still access the data they need!