The zhonya-ish enchanter item sounds uh... Interesting to play against. I'm not calling it broken before it even hits PBE, but "kill the soraka" is difficult enough as it is. If assassins can't reliably blow up squishy supports... Let's just say I hope they learned from Yuumi in that aspect.
The tank item that reduces damage is going to be pretty interesting. I honestly think its these kinds of designs that Riot should be going for. Instead of making broad "Everything is sunfire" items, making niche items that players can choose to opt into on a game-per-game basis just seems like the right way to go. This item (hopefully) cannot be built every game but in some games its optimal.
The change to make sanguine blade 1vX seems to indicate that it's not going to lose its power if multiple enemies arrive? Which is honestly huge. Not sure about the "more damage to towers if a tank is nearby" thing is going to be fun at all. This item might end up being giga toxic but we'll see.
Also, TIL Riot has a LGBTQIA+ lead. I mean, what do you even do with that job? Petition the narrative team to write some queer characters/stories? Make icons for Pride once a year? I'm sure there's a lot of work to do but I'm genuinely curious what a concrete work-week looks like.