Blows.
It's hard to know exactly who's doing what behind the scenes, but I feel like you can step back and look at the changes over the last two years of LCS, and kinda connect the dots easily enough to get an idea of the positive impacts she had.
I remember being very impressed when she first stepped into the role and seeing how much she wanted to learn, by asking questions and listening to fans, broadcast talent, players, orgs, etc. It was a very different approach to the job, and one I was very happy to see. She genuinely seemed to care a lot. Her first year seemed like a "ask questions, listen to what people are asking for, and learn as much as possible" with her second year being one of taking action with all the information she gathered. It was super nice to see, and it obviously started working really well. Imo the way she went about everything, given the circumstances, is exactly the way a leader should act. She was given a shit hand and still managed to turn it around pretty damn well.
I REALLY hope whoever comes next is able to learn a ton from her, and continue the path she carved out. I really don't want to go back to a corporate-feeling commissioner who doesn't actually care what the audience / players / broadcast talent want, but rather assume they know best.
That being said, this is obviously the correct choice for her, and I genuinely hope she is able to solve her health problems soon. Whatever it is she decides to do after sorting out her issues, I'm sure she'll crush it.