I play with a Kinesis Advantage keyboard, so I keep my fingers on "home position". Any game that uses WASD, I remap to ESDF.
I came to League directly from WoW, so I mapped the camera to ESDF, and spells to 1234.
I'm the reason there's a separate slider for mouse scroll speed vs. keyboard scroll speed; I turn mouse scroll speed waaaaay down so if I hit the edge of the screen I don't get completely disoriented.
Oh, and my keyboard is actually a custom Dvorak layout based on "Programmer's Dvorak", so I just described to you the QWERTY positions of the keys. If I were to type those "ESDF" keys, it would actually type ">OEU".
Edit: You can reach Gold 2 like that. ;-)