[2021] Cheats and achievements?

No, the ability to get achievements remains intact for that world.
As long as cheats are disabled when you actively try for the achievement, having previously enabled them does not seem to cause an issue.

Example a quick way to get the Player Killing achievements without killing another human.
Note: I can personally verify this works.
New game with cheats disabled.
F1 (to open console)
dm
cm
F1 (to close console)
U (open cheat menu)
Search for pipe bombs
Fill Belt with pipe bombs
Close cheat menu
press H
press space to fly up above the ground out of reachable distance for anything on ground.
Face a little bit in front and toward the ground of current position.
F6 (to open spawn menu)
Click the Spawn 25 box.
Press banditmelee twice
F6/ESC (to Close spawn menu)
F1 (to open console)
cm
dm
F1 (to close console)
NOTE: you should still be flying, and bandits still spawning or nearly fully spawned.
Drop pipe bombs till they're dead.
F1 (to open console)
dm
F1 (to close console)
F6 (to open spawn menu)
Press banditmelee twice
F6/ESC (to Close spawn menu)
F1 (to open console)
dm
F1 (to close console)
Drop pipe bombs till they're dead.

Repeat till you've killed 250.

Obviously the same could be done for the zombies, etc.

BTW - looks like a fun time if you do about 100 zombieStrippers at once.

Originally posted by GhostGaming: anyone know how to fix this spamming the console with, "NullReferenceException: Object reference not set to an instance of an object"???

Probably have to go back to A15 when that worked.