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Warhammer 40k has a group called Rogue Traders, they are like interstellar traders, explorers, corsairs. Many manage large fleets, colonies, and trading routes. They are also the only ones that can go outside the normal boundaries of the Imperium. I think this would be great with how the Anno series mechanics are.
Planets as small maps filled with islands (cold, temperate, jungle climates, etc.), great ships flying in the space above them fighting other enemies (other Rogue Traders, Orks, etc.). Maybe a star system would be like one giant map.
From the dev side, there is a lot of potential for DLCs. Adding more enemies, potential allies, and lots of strange mechanics (a corruption of the populace for example).
We could call it Anno 40,113. :P
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