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My question is if you can do more than one questline in a campaign. Or I must stick with a faction through all the game?

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over 1 year ago - /u/Regalis11 - Direct link

The questlines require certain levels of reputation for you to unlock them, and completing quests for a faction tends to heavily decrease the reputation for the opposing faction. It won't be easy, but it is possible to complete all of them in a single playthrough if you're careful on what missions you do and how you manage your reputation.