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What kind of coding gymnastics will they have to do so that DD is not affected by these specific keystones?
Exactly the same kind that has existed since closed beta to prevent the additional life monsters get from party size affecting detonate dead.
To be specific, Detonate Dead already uses "intermediary maximum life", which is a separate stat calculated from the base and applying most but not all modifiers. Further modifiers are applied to that stat to get actual max life used for the amount of life stuff has.
Is the application of non-damaging aliments (and stuns) effected by the extra life of wellspring of Creation? As they aren't effected by the extra life from party size according to the community wiki.
Is the application of non-damaging aliments (and stuns) effected by the extra life of wellspring of Creation?
Yes. Ailment Threshold (the amount of max life something is treated as having for calculating ailments/stuns) has been calculated separately from actual max life for a while now, and these keystones do apply to both.