This issue first started occurring when the Sledgehammer talent was introduced into the game.
Steps to reproduce:
- Play Dark Hours raid (normal)
- On the 3rd boss (Buddy/Lucy) use a weapon with either Sledgehammer or Perfect Sledgehammer talent
- Throw a grenade onto either Buddy or Lucy
Expected results: Sledgehammer debuffs the NPC so they take on more damage
Actual results: Buddy/Lucy won't die
Temporary solution: Everyone wipes, restarts the fight, and avoids the use of Sledgehammer