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I’d say it’s an apples to oranges scenario. They’re in the same group (fruit, for example), but they’re different items (different fruit). You should expect to engage in more melee mechanics in V2 than in Darktide, and most ranged will be used in a scenario with specials involved (maybe some elites depending on what you play). “Shields” do not regen, in the way you’re used to at least. Instead, depending on your talents, killing enemies will generate temp health that will decay unless replenished. The skill ceiling is near limitless and if you ever find yourself topping out, you can find mods in the workshop that make the game near impossible to beat, only limited by your CPU power.
Dodging will be your bread and butter as your block is limited. There’s less ranged enemies here, but once you get on solid footing, you can learn to dodge and attack at the same time to make the most of things. 
Speaking of mods, only a select handful of mods are approved for use in the “live realm.” You will find a “modded realm” where anything goes, and while the playerbase is smaller, it has its own dedicated playerbase that is happy to bring people into the fold.
Also good to note is that this game has no dedicated servers, but instead is peer to peer, so your PC’s CPU can affect enemy pathing and your internet can affect connection client-side. It’s generally recommend to avoid hosting if you fall into these camps.
That said, it has many different game modes for you try your hand at, as well as different ways to make the game more exciting in ways that bring a certain level of difficulty and excitement.