The experience as a returning player is always jarring and is an easy fix!!!

13 hours ago, 16Bitman said:

C:\Users\YourPCAccountName\AppData\Local\Warframe\A long set of numbers and letters\settings

Actually it's %localappdata%\warframe\EE.cfg for your keybinds. The "Settings" file is other stuff.

Keybinds are already preserved across versions, we've only messed with this a few times when there are serious problems with the keybind configuration. Are you saying you want the game to leave behind files even when uninstalled....?