One base challenge?

First and foremost, I have to have something that survives Day 7. And it’s hard to produce a base that can handle everything in one week. So I’ll typically make a temporary, early game horde base first, and use that while I work towards something stronger. During this phase I don’t bother trying to combine day base and horde base. It also gives time to explore the map, so I’m not building an ultimate base in a bad location.

With that caveat, yes, I’ve done multiple games where I fight the horde from part of my main base. What constitutes a “base” is amorphous… the horde fighting part might be in a different room or a different floor from the storage and crafting part of the base. But it’s one attached structure.

POI bases, underground bases, all-in-one bases, low tech bases, no-cheese bases… there are very few things a builder can’t do, if they’re determined.