[2020] Game and game time stopped - any thoughts

Let's try loading with the absolute minimum mods that your save needs to be functional. Disable everything but these:

Unlimited Oil And Ore
Unlimited Soil
Unlock All

Loading Screen Mod
Network Extensions 2
81 Tiles
Electric Roads Mod 2.1
Realistic Population Revisited 1.4.3
TM:PE 11.5.0 LABS
Remove Need For Pipes

Do NOT save, or if you do at least save as a new file! This is just to test if things behave like they should and if the transport lines still trigger the issue. If not, then we're looking for a mod doing something it shouldn't.

I haven't had a chance to try it, but I've seen this mod recommended instead of EDS. It works a little differently afaik, but maybe it will help you without causing problems.

https://steamcommunity.com/sharedfiles/filedetails/?id=1680840913&searchtext=transfer