Link to mod: https://mods.factorio.com/mod/MIRV
It used to be a little clunky to call down the nukes, so now it uses the artillery remote logic (which didn't exist 2 years ago when I first made the mod).
You can toggle the auto-target in the mod settings, along with whether to make pollution when it explodes or not (looks nice on the map too).
Internally now it uses a 'script trigger effect' which I added, which lets mods know when specific triggers happen, such as an artillery turret shooting at a nest.