As per title, several times now I've been unable to overwrite a revision to an existing Loadout. For example a better chest piece drops and I equip it, I press "R" (on PC) to overwrite it but the Loadout doesn't change.
There are no skills on cooldown etc that should prevent this.
Work around: create a new loadout or overwrite a completely different slot with the amended one you now want to save, rename it. Done. Also would suggest renaming or deleting the previous version. Drawback is that you have to have a "spare" loadout slot. Absolutely not something more dedicated players have!.