[2019] The game forgets Gameplay and Video settings

1. Press the Windows key + R
2. Enter %appdata% and select the ‘OK’ button
3. Navigate to AppData\Roaming\Fatshark\Vermintide 2
4. Right-click user_settings.config and select ‘Properties’

Under ‘Attributes’, is the ‘Read-only’ checkbox selected?

If so, please deselect it and apply the changes.

Set ‘Graphics Quality’ to ‘Custom’ to start with, and then apply your desired changes and click ‘Apply’. See if that works.