By default the skills that were QWERT are now QERFT. Of these, T is certainly the most annoying and I tend to avoid putting anything there that I need often.
I haven't found this to be an issue in practice. Typically the skills that have more of a "doing in motion" type aspect to them you put on the mouse. You have 3 buttons there.
Then the other skills tend to be more of the style where you use them at the right moment, and those work just fine on the other keys.