[2021] Eu4 not responding

This is just this one saved game, is that right? Or this happens in other campaigns too, or even new ones?  

If this game has had mods in it then I'm afraid we can't help with it here - disabling mods does not remove effects they have already had on the save game file.

But if you get any such issue in a save that's never had any mods used in it, do let us know!