4 months ago - AndrewT - Direct link
What happes if you run eu4.exe directly from File Explorer? Any Windows error show then?  
4 months ago - AndrewT - Direct link
That means that either your original Windows user profile is corrupt or bad in some way, OR it is running some app or utility that is getting in the way.

Int it, go into the startup apps area and disable everything, then reboot. Does EU4 then work?