A lot of good tips in this thread already, I think having a backround in other PDX games is a big help and might make things click easier. Even then everyone learns at their own pace so my personal advice is to play for fun and try to avoid a mindset of if you have "Done well".
I will shamelessly plug our
player resources[pdxint.at] post as well, some of the resources there may be useful if you're trying to learn the game. Good luck and hope you can find some enjoyment out of the learning process itself :D