[2022] Mouse not Responding?

I don't know the "Technical" terms so I will try to explain

Normally the game "Takes over" the mouse - so when you move your mouse you aim.
But for some random reason the mouse "popped out" ? where you see the mouse cursor.

Like when you press esc - to see your "mouse"
except it happened in game. So I had no way to turn, or extract,

I tried using Shift F2 to hope it would go back
Pressed Esc
Alt tabbed and back

Nothing seemed to return the "mouse" to the game.

I got a 100 hours into the game this never happened before.