How difficult are the harder difficulties compared to balatro stakes (Which i assumed you played), because story was quite easy, but it should be considering how much time I wasted in baltro
They're a fair bit harder, but basically similar to green stake; not gameplay or system modifiers. They make enemies more challenging, build synergy more required, and lingering damage more dangerous.
For an experienced player who understands the systems, they're not going to take tons of attempts, but they should at least provide a meaningful challenge.