I suspect the same SPM megabases will be possible as it will be done with fewer machines that have higher throughput at high quality. The question is more about can we go higher or not.
We expect (and try to prepare) for bigger factories overall. We didn't really introduce any significant performance penalties with the new mechanics.
You obviously need more stuff to be done to do the end research, as you need to produce the base game stuff + science pack on each planet + the silo transport and space platforms update.
This is partially (if not fully) offset by more performant machines, and we are planning to do some optimisations on top of that.