There's a bug thats been in the game since launch that EHG just seems to either be unable to fix or somehow still doesn't know about.
If you press x while an item is dropping, its nameplate gets deleted and you can never pick it up. Enabling filters, item names, etc does nothing. The item is on the ground, you can see it and its light pillar but there is nothing you can do to ever interact with it ever again.
My advice is to unbind the x key so you don't accidentally bug your loot.
I think I saw this come through recently but it was worded differently and I couldn't reproduce it so I put it in the wait for more detailed repro steps category. Not sure if it was from you or not.